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Apoptosis describes a programmed mode of cell death that is characterized by a series of biochemical events that ultimately lead to cell fragmentation into compact membrane-enclosed structures, called apoptotic bodies that are taken up by neighboring cells and phagocytes, preventing inflammation, and tissue damage (Taylor et al., 2008)
The obtained concentration time-series after model parameter estimation for using the individual experimental data leads to a personally parametrized model that can be used as a decision support tool to develop individually tailored precision therapy to reach the necessary metformin concentrations in the target tissues
NMA, network meta-analysis
van Hall G
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